2. Signaling Pathways
  3. GPCR/G Protein
  4. Adhesion G Protein-coupled Receptors (AGPCRs)

Adhesion G Protein-coupled Receptors (AGPCRs)

Adhesion G Protein-coupled Receptors (AGPCRs)

dhesion G Protein-Coupled Receptors (AGPCRs) are a subfamily of the G protein-coupled receptor (GPCR) superfamily, primarily mediating cell adhesion, cell-cell communication, and signal transduction, playing crucial roles in neural development, immune regulation, angiogenesis, and cancer progression.
The AGPCR family consists of 33 members, categorized based on function into immune-related types (e.g., ADGRE1-5), development and nervous system-related types (e.g., ADGRG1, ADGRL3), and cardiovascular regulatory types (e.g., ADGRA2), all designated with the "ADGR" prefix. A distinctive feature of AGPCRs is their long extracellular N-terminal domain and GPS (G protein-coupled receptor proteolytic site), which enables self-activation via the “Stachel” domain upon external stimulation, facilitating signal transduction.
Dysfunction of AGPCRs is associated with brain developmental disorders, inflammatory diseases, infertility, and various cancers. For instance, mutations in ADGRG1 (GPR56) can cause bilateral frontoparietal polymicrogyria (BFPP), mutations in ADGRE2 are linked to vibratory urticaria, and deficiency of ADGRG2 (GPR64) may result in congenital bilateral absence of the vas deferens (CBAVD). Additionally, GPR56 plays a key role in melanoma metastasis and glioma progression. With advancing research into AGPCR structure and function, this family has become a major focus in the study of neurological disorders, immune diseases, and cancer[1][2].

Adhesion G Protein-coupled Receptors (AGPCRs) Related Products (3):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-16950A
    (E/Z)-4-Hydroxytamoxifen
    		Activator 99.62%
    (E/Z)-4-Hydroxytamoxifen (Afimoxifene) is a racemic compound of (Z)-4-Hydroxytamoxifen and (E)-4-Hydroxytamoxifen isomers. (E/Z)-4-Hydroxytamoxifen is a selective estrogen receptor modulator with mixed estrogenic and antiestrogenic activity, which is also an active metabolite of Tamoxifen (HY-13757A). (E/Z)-4-Hydroxytamoxifen is an agonist of the G protein-coupled estrogen receptor (GPER) with relatively low affinity (100-1000 nM). (E/Z)-4-Hydroxytamoxifen is promising for research of cyclical mastalgia, such as breast pain, tenderness, and nodularity.
    (E/Z)-4-Hydroxytamoxifen
  • HY-P10365
    VPM-p15
    		Agonist 98.18%
    Vmm-p15 is a peptide agonist optimized for the adhesion G protein-coupled receptor GPR64 (also known as ADGRG2 or HE6). The affinity of VPM-p15 with GPR64 is significantly higher than that of the original p15 peptide. The cAMP level induced by VMM-P15 increased significantly, activated GPR64, and triggered downstream Gs, Gq, and G12/13 signaling. VPM-p15 can be used to study the activation mechanism of adherent GPCR family members.
    VPM-p15
  • HY-P3942
    SDP116
    		Inhibitor 98.65%
    SDP116 is a synthetic Stachel-derived peptide of GPR116 Stachel peptide. SDP116 has ADGRF5 agonist effect.
    SDP116